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Table 1 Formal definitions of the measures employed by the current study and their abbreviations used in accompanying figures

From: Endogenous cholinergic tone modulates spontaneous network level neuronal activity in primary cortical cultures grown on multi-electrode arrays

Measure name Abbreviated label used in figures Formal definition
Network spike rate Not applicable Total number of spike events occurring on all channels within a 4 ms bin.
Network spike profile Not applicable Network spike rate vs time during global burst events. T0 is defined by the time at which the bin containing the maximum rate occurred and is based on the Simmux algorithm [17].
Spikes per channel during global bursts C-spikes Number of spike events per channel during a global burst event.
Spikes on all channels during global bursts G-spikes The sum of spike events occurring on all channels during a global burst event.
Active channels during global bursts C-active Number of channels showing spiking activity during a global burst event when single channel burst criteria are met; see Methods.
Burst duration (channel) C-duration Time between first and last spike events on a channel during a global burst event.
Burst duration (global) G-duration Time between first and last spike events on all participating channels during a global burst event.
In-burst ISI ISI-burst Mean interspike interval derived from all events occurring on all channels during a global burst event.
Overall ISI ISI-all Mean interspike interval derived from all events occurring on all channels during a given recording.
Proportion of spikes occurring in bursts SIB ‘Spikes in bursts’: spike events occurring within global burst events as a proportion of the total number of spike events occurring during a recording.
Inter-burst interval IBI ‘Inter-burst interval’: time between the last spike of a preceding burst event and the first spike of the next burst event.