Figure 7

mAChR blockade by atropine (1 μM) modulates spontaneous neuronal activity in cortical cultures recorded via MEA. (A) Network spike profile (see Table 1) for immature (grey) and mature (black) cultures presented as normalised change from control following mAChR blockade. (B) The effect of atropine upon the distribution of interburst intervals in immature (grey) and mature (black) cortical cultures. (C) The effect of atropine upon the number of spikes occurring on individual channels during bursting.