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Figure 10 | BMC Neuroscience

Figure 10

From: Endogenous cholinergic tone modulates spontaneous network level neuronal activity in primary cortical cultures grown on multi-electrode arrays

Figure 10

The effect of mAChR and nAChR blockade on the network spike profile and the correlation between starting state and mAChR-mediated response. (A) Network spike profile (see Table 1) for immature (grey) and mature (black) cultures presented as normalised change vs. control following combined mAChR plus nAChR blockade by atropine (1 μM) and mecamylamine (10 μM) respectively. (B) The relationship between starting state and extent of change following mAChR activation by OXO-M (10 μM) in mature cultures where ■  = global burst duration and ●  = single channel burst duration.

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BMC Neuroscience

ISSN: 1471-2202

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