Changes in APE1 mRNA and protein levels. A-mRNA was determined using qRT-PCR. A significant reduction (p < 0.01) in group 2a at 4 weeks of induction was observed. APE1 mRNA was elevated during self-recovery (group 2a at week 8) as well as during the four weeks of resveratrol treatment. Pre- and cont- resveratrol administration maintained significantly elevated (p < 0.01) APE1 compared to induced group. B- APE1 protein profile shows the same pattern and change in parallel to mRNA as indicated in all groups. C-Immunohistochemical analysis of continuously resveratrol administered group indicated strong cytoplasmic expression of APE1. * indicates significance from control at p < 0.01, while ** indicates significance between groups at p < 0.05.