Anxiety-related behavioral alterations caused by repeated nicotine (NC) and/or immobilization stress (IM) in the elevated plus-maze (EPM) test. Data are presented for percentage of entries into open arms (a) and percentage of time spent on open arms (b). The values at the 2 h time point after the last NC (0.3 or 0.8 mg/kg, s.c.) or IM treatment are shown as means ± S.D. (n=10 for each group). aa (p<0.01): significant attenuation as compared to the control group; cc (p<0.01): significant attenuation as compared to the IM group.