Figure 7
From: c-Jun N-terminal kinase in synergistic neurite outgrowth in PC12 cells mediated through P90RSK
P90RSK is regulated by Erk and JNK in the NP and FP systems, but only by Erk in the EP system. (a), (b), (c) Time-course measurement of pP90RSK at 20 and 60 minutes following NGF (50 ng/ml)-PACAP (100 ng/ml), FGFb (50 ng/ml)-PACAP (100 ng/ml), and EGF (50 ng/ml)-PACAP (100 ng/ml) treatment, respectively, in the presence or absence of MEK inhibitor, U0126 (20 μM), or JNK inhibitor, SP600125 (10 μM). Significant differences between treatments with and without inhibitors were calculated using the paired Student’s t-test. A value of p < 0.05 was considered significant (**p < 0.01).