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Table 2 NIH DAVID functional annotation clustering of autism-associated genes found to be significantly altered in postpartum LS

From: Development of a versatile enrichment analysis tool reveals associations between the maternal brain and mental health disorders, including autism

Cluster Enrichment score Genes
Synapse/Cell Junction 7.69 Cadps Ctnnb1 Gabrd Pclo Syt6
   Rasgrp2 Cplx2 Grik1 Scn1a  
   Snapin Cpeb1 Grm3 Sv2c  
   Adora2a Dlg1 Lrfn1 Synpr  
   Camk2a Gabra4 Phactr1 Syt5  
Regulation of synaptic plasticity/transmission 4 Hras1 Drd1a    
   Adora2a Grik1    
   Camk2a Grm3    
   Cpeb1     
   Drd2     
Neuron projection morphogenesis 3.75 Dscam Adora2a Gas7   
   Klf7 Baiap2 Nr2e1   
   Sh2b1 Ctnnb1 Phgdh   
   Slitrk1 Cxcr4 Actg1   
   Alcam Drd2 Robo2   
Cyclic nucleotide mediated signaling 3.35 Htr5a Pclo    
   Adora2a Tshr    
   Drd2     
   Drd1a     
   Gna11     
Cell morphogenesis/differentiation 2.73 Dscam Cxcr4    
   Klf7 Drd2    
   Slitrk1 Nr2e1    
   Alcam Robo2    
   Ctnnb1     
Neurogenesis/nervous system development 2.48 Ascl1 Smo    
   Ctnnb1 Robo2    
   Drd2 Socs2    
   Mapt     
   Nr2e1     
Regulation of glutamine/amine/GABA signaling 2.44 Adora2a     
   Drd2     
   Drd1a     
   Grik1     
   Nnat     
Cell motility/migration 2.4 Flt1 Drd1a    
   Ascl1 Nr2e1    
   Cxcr4 Pex5l    
   Cx3cl1 Smo    
   Drd2     
  1. Enrichment scores were calculated for all 160 autism-associated genes found in significant postpartum LS results (FDR-adjusted p < 0.25, Additional file 2: Table 2) by NIH DAVID’s functional annotation clustering with “high” stringency setting selected.