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Table 2 NIH DAVID functional annotation clustering of autism-associated genes found to be significantly altered in postpartum LS

From: Development of a versatile enrichment analysis tool reveals associations between the maternal brain and mental health disorders, including autism

Cluster

Enrichment score

Genes

Synapse/Cell Junction

7.69

Cadps

Ctnnb1

Gabrd

Pclo

Syt6

  

Rasgrp2

Cplx2

Grik1

Scn1a

 
  

Snapin

Cpeb1

Grm3

Sv2c

 
  

Adora2a

Dlg1

Lrfn1

Synpr

 
  

Camk2a

Gabra4

Phactr1

Syt5

 

Regulation of synaptic plasticity/transmission

4

Hras1

Drd1a

   
  

Adora2a

Grik1

   
  

Camk2a

Grm3

   
  

Cpeb1

    
  

Drd2

    

Neuron projection morphogenesis

3.75

Dscam

Adora2a

Gas7

  
  

Klf7

Baiap2

Nr2e1

  
  

Sh2b1

Ctnnb1

Phgdh

  
  

Slitrk1

Cxcr4

Actg1

  
  

Alcam

Drd2

Robo2

  

Cyclic nucleotide mediated signaling

3.35

Htr5a

Pclo

   
  

Adora2a

Tshr

   
  

Drd2

    
  

Drd1a

    
  

Gna11

    

Cell morphogenesis/differentiation

2.73

Dscam

Cxcr4

   
  

Klf7

Drd2

   
  

Slitrk1

Nr2e1

   
  

Alcam

Robo2

   
  

Ctnnb1

    

Neurogenesis/nervous system development

2.48

Ascl1

Smo

   
  

Ctnnb1

Robo2

   
  

Drd2

Socs2

   
  

Mapt

    
  

Nr2e1

    

Regulation of glutamine/amine/GABA signaling

2.44

Adora2a

    
  

Drd2

    
  

Drd1a

    
  

Grik1

    
  

Nnat

    

Cell motility/migration

2.4

Flt1

Drd1a

   
  

Ascl1

Nr2e1

   
  

Cxcr4

Pex5l

   
  

Cx3cl1

Smo

   
  

Drd2

    
  1. Enrichment scores were calculated for all 160 autism-associated genes found in significant postpartum LS results (FDR-adjusted p < 0.25, Additional file 2: Table 2) by NIH DAVID’s functional annotation clustering with “high” stringency setting selected.