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Table 1 Genes with strong links to autism found in significant postpartum LS expression changes

From: Development of a versatile enrichment analysis tool reveals associations between the maternal brain and mental health disorders, including autism

Gene symbol

Gene name

Autism databases

Foxp2

Forkhead box P2

7

Sez6l2

Seizure related 6 homolog like 2

7

Lamb1

Laminin B1

7

Slc1a1

Solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1

7

Adora2a

Adenosine A2a receptor

6

Gabra4

Gamma-aminobutyric acid (GABA) A receptor, subunit alpha 4

5

Hras1

Harvey rat sarcoma virus oncogene 1

5

Arnt2

Aryl hydrocarbon receptor nuclear translocator 2

5

Lrfn5

Leucine rich repeat and fibronectin type III domain containing 5

4

Scn1a

Sodium channel, voltage-gated, type I, alpha

4

Drd2

Dopamine receptor D2

4

Nostrin

Nitric oxide synthase trafficker

4

Npy

Neuropeptide Y

4

Snrpn

Small nuclear ribonucleoprotein N

4

Fabp5

Fatty acid binding protein 5, epidermal

4

Pcdh10

Protocadherin 10

4

Kcnd2

Potassium voltage-gated channel, Shal-related family, member 2

3

Upp2

Uridine phosphorylase 2

3

Rbfox1

RNA binding protein, fox-1 homolog (C. elegans) 1

3

Adra2a

Adrenergic receptor, alpha 2a

3

Cadps2

Ca2 + −dependent activator protein for secretion 2

3

Camk2b

Calcium/calmodulin-dependent protein kinase II, beta

3

Csmd3

CUB and Sushi multiple domains 3

3

Drd1a

Dopamine receptor D1A

3

Fabp7

Fatty acid binding protein 7, brain

3

Foxo1

Forkhead box O1

3

Hcrtr1

Hypocretin (orexin) receptor 1

3

Htr5a

5-hydroxytryptamine (serotonin) receptor 5A

3

Mchr1

Melanin-concentrating hormone receptor 1

3

Nr2e1

Nuclear receptor subfamily 2, group E, member 1

3

Oprk1

Opioid receptor, kappa 1

3

Pde4b

Phosphodiesterase 4B, cAMP specific

3

Ppp1r1b

Protein phosphatase 1, regulatory (inhibitor) subunit 1B

3

Rarb

Retinoic acid receptor, beta

3

Robo2

Roundabout homolog 2 (Drosophila)

3

Tac1

Tachykinin 1

3

  1. All genes in Table 1 have expression changes with FDR-adjusted p-values less than 0.25. The farthest right hand column shows the number of autism databases in which the gene was featured, and represents a putative strength of evidence for a positive association to autism. Only genes that appeared in three or more lists are shown here. A full list of autism-associated genes from all databases found in postpartum LS expression changes is provided in Additional file 2: Table S2.