Figure 4

MSET evaluation of enrichment for autism and arthritis-associated genes within expression data from a murine arthritis model and postpartum LS. The left hand column of windows features the graphical output of MSET enrichment analyses for representative arthritis-associated gene lists (top three windows) and selected autism-associated gene lists (bottom two windows) within expression data from a mouse model of induced arthritis. The right hand column of windows shows the graphical assessment of enrichment for representative arthritis-associated genes within postpartum LS expression results. Y-axis represents the probability of X matches to database found in a randomly generated set of simulated results from the microarray background. The red arrow shows how many matches were found in the actual significant arthritis model expression changes and where that number falls on the probability density distribution, while the blue arrow represents matches in the actual significant postpartum LS expression results. The enrichment p-values are derived from the number of simulated results that contained at least as many matches to database as the actual results.