Skip to main content
Figure 4 | BMC Neuroscience

Figure 4

From: Dopaminergic tone regulates transient potassium current maximal conductance through a translational mechanism requiring D1Rs, cAMP/PKA, Erk and mTOR

Figure 4

PKA antagonist Rp-cAMP blocks DA induced increase in I A G max . A. The specific PKA antagonist Rp-cAMP was applied in conjunction with TTX for 1 hr (with or without DA) followed by a 3 hr washout, and 1 hr block. Rp-cAMP and TTX were applied 10 min before administration of DA. B. 1 mM Rp-cAMP blocked the DA induced increase in IA Gmax, and was significantly different than TTX + DA alone, indicating that the persistent effect is dependent of PKA. Data were analyzed with ANOVAs, Tukey’s post hoc that makes all pairwise comparisons and plotted as mean ± S.D.

Back to article page

BMC Neuroscience

ISSN: 1471-2202

Contact us