Table 2 Fluxes of the basic model
Fluxes in μM·h−1 | ||||
|---|---|---|---|---|
Basic model | ||||
Reaction (group) | maxApo | minApo | maxDeg | minDeg |
ROS production (DA) | 19.00 | 19.00 | 19.56 | 19.00 |
ROS production (mitochondria, complex I) | 21.15 | 0.00 | 0.00 | 0.00 |
ROS production (mitochondria, complex III) | 46.04 | 26.05 | 35.06 | 23.35 |
ROS elimination (DJ-1) | 0.00 | 0.00 | 0.00 | 0.00 |
ROS damage (protein) | 14.98 | 22.73 | 35.17 | 20.31 |
ROS damage (mitochondria) | 50.00 | 25.92 | 28.23 | 26.21 |
ROS damage (DNA) | 5.00 | 0.00 | 0.00 | 5.00 |
Apoptosis (LBs) | 35.00 | 0.00 | 0.00 | 0.00 |
Apoptosis (mitochondria) | 65.00 | 0.00 | 2.40 | 6.47 |
Degradation (lysosome) | 4.98 | 10.58 | 27.27 | 0.00 |
Degradation (proteasome) | 0.00 | 0.00 | 0.00 | 0.00 |
Degradation (mitophagy) | 0.00 | 10.43 | 17.73 | 0.00 |
Biogenesis of mitochondria | 5.00 | 0.00 | 0.00 | 5.00 |
Extracellular DA | 0.80 | 0.80 | 0.80 | 0.80 |
αSYN aggregation | 36.00 | 9.89 | 4.24 | 10.00 |
αSYN output reaction | 0.00 | 0.00 | 0.00 | 0.00 |
Toxic effect of αSYN aggregates | 0.00 | 0.00 | 0.00 | 0.00 |
Inhibition of αSYN aggregation by DJ-1 | 1.00 | 9.89 | 4.24 | 10.00 |