Skip to main content

Table 1 Parameters and target functions of the flux balance analyses

From: Parkinson’s disease: dopaminergic nerve cell model is consistent with experimental finding of increased extracellular transport of α-synuclein

Experiment

Performed FBA with the

Flux range

 

corresponding target function

[μM·h−1]

Normal nerve cell

minApo, maxApo, minDeg, maxDeg

-

O2

minApo, maxDeg

0-100

ATP

minApo, maxDeg

0-1000

Drug influence (MPTP)

minApo, maxDeg

0-100

Increased αSYN flux

minApo, maxDeg

0-100

Increased tyrosine flux

minApo, maxDeg

0-100

  1. Six experiments were performed. For each experiment, at least two different FBAs were performed with different target functions and variable flux ranges that are denoted in the last table column. Abbreviations: minimizing the output-reaction of the apoptosis (minApo), maximizing the output-reaction of the apoptosis (maxApo), minimizing the output-reaction of the degradation (minDeg), maximizing the output-reaction of the degradation (maxDeg), 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).