Skip to main content

Table 1 Parameters and target functions of the flux balance analyses

From: Parkinson’s disease: dopaminergic nerve cell model is consistent with experimental finding of increased extracellular transport of α-synuclein

Experiment Performed FBA with the Flux range
  corresponding target function [μM·h−1]
Normal nerve cell minApo, maxApo, minDeg, maxDeg -
O2 minApo, maxDeg 0-100
ATP minApo, maxDeg 0-1000
Drug influence (MPTP) minApo, maxDeg 0-100
Increased αSYN flux minApo, maxDeg 0-100
Increased tyrosine flux minApo, maxDeg 0-100
  1. Six experiments were performed. For each experiment, at least two different FBAs were performed with different target functions and variable flux ranges that are denoted in the last table column. Abbreviations: minimizing the output-reaction of the apoptosis (minApo), maximizing the output-reaction of the apoptosis (maxApo), minimizing the output-reaction of the degradation (minDeg), maximizing the output-reaction of the degradation (maxDeg), 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).