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Table 1 Age by which a 50% decrease in the mean test performance of each group had occurred, or a 25% decrease in the case of the footprint test, within a confidence interval of one week, determined from the mathematical models established

From: Parkin depletion delays motor decline dose-dependently without overtly affecting neuropathology in α-synuclein transgenic mice

  Amplitude of extension reflex score < 2.5 Rotarod time on rod < 90 s Symmetry of extension reflex score < 1 Stride length < 5 cm
hA30Pα-syn+/+ 18.1 ± 0.2 months 19.3 ± 0.2 months 20.0 ± 0.2 months 20.7 ± 0.2 months
parkin+/-; hA30Pα-syn+/+ 18.4 ± 0.2 months 20.2 ± 0.2 months 22.3 ± 0.2 months 23.0 ± 0.2 months
parkin-/-; hA30Pα-syn+/+ 21.0 ± 0.2 months 23.2 ± 0.2 months 23.4 ± 0.2 months > 24 months