Figure 5

IGFBP-4 mRNA expression in postnatal rat brains. (A) The temporal expression of IGFBP-4 mRNA in specific brain regions. (In the cerebral cortex, *- the level of IGFBP-4 mRNA at P0 is significantly lower than at other time-points, ★- the level of IGFBP-4 mRNA at P21 is significantly higher than at other time-points; In the cerebellum, *- the level of IGFBP-4 mRNA at P21 is significantly lower than at other time-points, ★- the level of IGFBP-4 mRNA at P70 is significantly higher than at other time-points; In the midbrain, *- the level of IGFBP-4 mRNA at P28 is significantly lower than at other time-points, ★- the level of IGFBP-4 mRNA at P0 is significantly higher than at other time-points; all P < 0.05) (B) The spatial expression of IGFBP-4 mRNA at specific time-points. (At P0, *- the level of IGFBP-4 mRNA in cerebral cortex is significantly lower than in other brain regions; ★- IGFBP-4 mRNA in midbrain is significantly higher than in other brain regions. At P7, P21, P28 and P70, *- the level of IGFBP-4 mRNA in midbrain is significantly lower than in other brain regions; ★- IGFBP-4 mRNA in cerebral cortex is significantly higher than in other brain regions. At P14, *- the level of IGFBP-4 mRNA in cerebellum is significantly lower than in other brain regions; ★- IGFBP-4 mRNA in cerebral cortex is significantly higher than in other brain regions; all P < 0.05) (F-female rat).