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Figure 4 | BMC Neuroscience

Figure 4

From: The effects of different doses of estradiol (E2) on cerebral ischemia in an in vitro model of oxygen and glucose deprivation and reperfusion and in a rat model of middle carotid artery occlusion

Figure 4

The effects of different doses of E2 pre-treatment on PC12 cell viability and cell damage. (A) MTT assay was used to test the cell viability after OGD-R. 10 nM and 20 nM E2 significantly promoted the cell viability. The cell viability in the cells treated with 10 μM and 20 μM E2 group significantly decreased. (*p < 0.01 compared with the control and DMSO groups, #p < 0.05 compared with the control and DMSO groups). (B) LDH release assay was used to detect cell necrosis after OGD-R. 10 nM and 20 nM E2 did not significantly attenuate LDH release; and 10 μM and 20 μM E2 the LDH release in group had not markedly declined (v.s. the control and DMSO groups).

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BMC Neuroscience

ISSN: 1471-2202

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