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Table 1 The mean (± SEM) of the percentage of BrdU+ cells that are Iba1+, S100β+, Olig2+ and NeuN+ per animal in the defined regions of the brain of GFP-global mutant (n=4) and GFP-control (n=4) mice

From: Phenotyping dividing cells in mouse models of neurodegenerative basal ganglia diseases

 

Motor Cortex

Striatum

Periventricular Region

Mutant

Control

Mutant

Control

Mutant

Control

Iba1+

23.2 ± 7.9

0.4 ± 0.4

37.7 ± 5.6

12.0 ± 6.3

22.5 ± 2.3

6.8 ± 1.4

S100β+

18.5 ± 4.9

16.9 ± 4.2

1.8 ± 0.7

2.7 ± 0.5

2.7 ± 0.1

2.5 ± 0.9

Olig2+

49.8 ± 9.8

78.3 ± 1.1

17.3 ± 1.4

58.2 ± 11.3

21.4 ± 2.9

26.0 ± 3.9

NeuN+

7.8 ± 0.9

9.2 ± 2.1

2.2 ± 0.2

1.5 ± 0.5

2.9 ± 0.8

1.7 ± 0.7

Marker-negative*

0.7

0

41.0

25.6

50.5

63.0

  1. * refers to the percentage of BrdU+ cells that did not label with any of the four antibodies. This was calculated as the difference between the sum of the percentages for the panel of four antibodies and 100. This calculation assumes that the selected lineage specific antibodies are indeed specific and BrdU positive cells in this study co-express only one lineage marker.
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BMC Neuroscience

ISSN: 1471-2202

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