Figure 8

Regional quantification of Ki67+ cells in GFP-control, GFP-global, global-mutant, cortical-mutant and control lines. (A) The distribution of Ki-67+ cells relative to bregma on the striatal side of the periventricular region in the brain of GFP-global mutant and GFP-control mice analysed at 80 weeks post-natal. Each point represents the mean ± SEM at a specific distance from bregma in mutant (n=4) and control (n=4) mice. There were fewer Ki-67+ cells in mutant mice, the difference being significant at the three most cranially located points of 1.18 (**P<0.01), 0.50 (*P<0.05) and 0.26 (**P<0.01) mm from bregma as determined by a Bonferroni post-hoc test. (B) The distribution of Ki-67+ cells relative to bregma in the striatal side of the periventricular region of the brain of mutant mice belonging to the global and cortical lines and global line littermate age matched control mice. Each point represents the mean ± SEM as determined for each distance from bregma in mutant (n=4) and control (n=4) mice. In each line, there were fewer Ki-67+ cells in mutant relative to control mice with the difference being significant at 1.18 mm from bregma (**P<0.01) as determined by a Bonferroni post-hoc test.