Figure 2

Regional quantification of dividing cells in GFP-control and GFP-global mutant mice. Bar graphs showing the number of BrdU+ cells in each brain region of control (GFP-control) and mutant mice from the GFP-global (A), and control and striatal lines (B). Each bar represents the mean (± SEM) of the cumulative number of BrdU+ cells per mutant (n=4) or control (n=4) as determined from five coronal sections per mouse obtained between 1.18 mm to −0.46 mm from bregma. Asterisks refer to the results of the 2-way ANOVA using the original cell counts. There was a main effect of genotype in the form of a greater number of BrdU+ cells in the cortex (**P<0.01), striatum (***P≤0.0001) and periventricular region (**P<0.01) of the GFP-global relative to GFP-control lines. There was a main effect of genotype in the form of a greater number of BrdU+ cells in the striatum (*P<0.05) and periventricular region (*P<0.05) of striatal line relative to control mice.