Figure 2

General health. Monitoring of survival rates up to the age of 10 months revealed no significant differences between hom E8 (A) or het/het E85 mice (B) compared to wt animals, respectively; dots represent dead or censored animals; data were analyzed by logrank test of survival curves; p > 0.05; n ≥ 50 animals per group. Monitoring of bodyweight revealed a moderate, but not significantly reduced gain of weight for hom E8 (C); data of each gender were analyzed by two-way ANOVA for repeated measurements followed by Bonferroni’s post hoc test (factor genotype, n.s. p > 0.05) and represent means ± SEM; n = 4–10 animals per group. A similar reduction of weight gain was observed in het/het E85 (D) compared to wt animals; data of each gender were analyzed separately by two-way ANOVA for repeated measurements followed by Bonferroni’s post hoc test (factor genotype, n.s. p > 0.05) and represent means ± SEM; n = 10–16 animals per group.