Figure 4

Comparison of gene set properties to functional GO groups. Histograms represent z-score distributions for cluster coefficient (A, B) and shortest path length (C, D) computed across 3,230 different GO groups in the control and schizophrenia networks. Z-scores represent the difference between the mean value of the network measure of the GO group compared to the mean of random gene sets of the same size and matched node degree. Dashed lines plotted represent the z-score obtained for the down-regulated meta-signature gene set and solid lines represent the z-score obtained for the up-regulated gene set. Z-score values for selected brain-related disease gene sets are displayed as coloured arrows on the x-axis. ALZ Alzheimer’s disease; PD Parkinson’s disease.