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Table 2 Monoamines and their metabolites in the cortex and striatum of mGlu2 −/− and mGlu3 −/− mice and their respective wild-type (WT) littermates

From: Decreased striatal dopamine in group II metabotropic glutamate receptor (mGlu2/mGlu3) double knockout mice

 

mGlu2 WT

mGlu2−/−

mGlu3 WT

mGlu3−/−

 

Cortex

Dopamine

0.5 +/− 0.08

0.4 +/− 0.07

0.4 +/− 0.04

0.4 +/− 0.05

DOPAC

0.2 +/− 0.03

0.2 +/− 0.01

0.2 +/− 0.02

0.2 +/− 0.03

Noradrenaline

2.0 +/− 0.18

1.8 +/− 0.16

2.2 +/− 0.19

2.3 +/− 0.22

MHPG

0.6 +/− 0.05

0.6 +/− 0.05

0.7 +/− 0.10

0.8 +/− 0.07

5-HT

3.1 +/− 0.19

3.1 +/− 0.23

3.1 +/− 0.20

2.9 +/− 0.25

5-HIAA

1.0 +/− 0.03

0.8 +/− 0.06

0.8 +/− 0.08

0.7 +/− 0.06

 

Striatum

Dopamine

34.0 +/− 3.8

36.5 +/− 3.8

35.7 +/− 4.7

32.6 +/− 3.3

DOPAC

2.3 +/− 0.2

2.4 +/− 0.2

2.1 +/− 0.1

2.2 +/− 0.2

HVA

2.8 +/− 0.2

3.1 +/− 0.2

2.3 +/− 0.2

3.0 +/− 0.3

Noradrenaline

2.0 +/− 0.2

1.8 +/− 0.2

1.5 +/− 0.1

1.6 +/− 0.1

5-HT

2.9 +/− 0.2

3.1 +/− 0.2

3.6 +/− 0.2

3.5 +/− 0.3

5-HIAA

1.6 +/− 0.1

1.6 +/− 0.1

1.6 +/− 0.1

1.8 +/− 0.03

  1. n=6-8 in each group. Values are pmol/mg tissue, mean ± SEM. There are no significant differences between groups. Reliable measurements for cortical HVA and striatal MHPG could not be obtained.