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Table 1 Monoamines and their metabolites in the cortex and striatum of mGlu2/3 −/− double knockout and wild-type (WT) mice

From: Decreased striatal dopamine in group II metabotropic glutamate receptor (mGlu2/mGlu3) double knockout mice

 

Cortex

Striatum

 

mGlu2/3 WT

mGlu2/3−/−

mGlu2/3 WT

mGlu2/3−/−

Dopamine

1.7 +/− 0.51

1.4 +/− 0.34

49.8 +/−3.38

37.8 +/− 2.40a

DOPAC

0.6 +/− 0.13

0.5 +/− 0.09

3.8 +/− 0.23

2.7 +/− 0.22b

HVA

0.8 +/− 0.10

0.9 +/− 0.12

4.9 +/− 0.33

3.9 +/− 0.28c

Noradrenaline

1.6 +/− 0.08

1.8 +/− 0.07

1.4 +/− 0.07

1.6 +/− 0.15

MHPG

2.2 +/− 0.17

2.9 +/− 0.14d

4.3 +/− 0.38

4.2 +/− 0.41

5HT

2.9 +/− 0.13

3.1 +/− 0.09

3.5 +/− 0.20

3.6 +/− 0.23

5HIAA

1.1 +/− 0.08

1.3 +/− 0.08

1.8 +/− 0.11

1.8 +/− 0.12

  1. n=12-16 mGlu2/3−/− mice, and 12–14 WT mice. Values are pmol/mg tissue, mean ± SEM.
  2. aF1,26 = 9.25, p=0.005.
  3. bF1,26 = 9.85, p=0.004.
  4. cF1,26 = 5.84, p=0.023.
  5. dF1,24 = 11.1, p=0.003.