Skip to main content
Figure 7 | BMC Neuroscience

Figure 7

From: PI3K/Akt-independent negative regulation of JNK signaling by MKP-7 after cerebral ischemia in rat hippocampus

Figure 7

Model of JNK inhibition after cerebral ischemia/reperfusion. JNK activity can be elevated by activated ASK-SEK1 or MLK3-MKK-7, or be downregulated by dephosphorylation of JNK at Thr183/Tyr185 by specific phosphatases MKP-7 following ischemia/reperfusion. MKP-7 function is increased by its nuclear-to-cytoplasmic translocation, which ultimately inhibits JNK activity. Active Akt (which inactivates SEK1 by phosphorylation Ser80 and inhibits MKK-7 by MLK3 phosphorylation at Ser674) does not affect down-regulation of JNK activity induced by MKP-7 after ischemia in the rat hippocampus.

Back to article page

BMC Neuroscience

ISSN: 1471-2202

Contact us