Table 1 Summary of IPA Ingenuity analysis for the upper, middle, and deep cortical zones
IPA Ingenuity Pathway Analysis 317 GENES (ALL) | ||||
|---|---|---|---|---|
Diseases and Disorders | p-value | #genes | ||
Neurological Disease | 2.40E-21 | - | 1.99E-02 | 164 |
Psychological Disorder | 3.15E-16 | - | 1.99E-02 | 85 |
Genetic Disorder | 7.48E-16 | - | 1.99E-02 | 213 |
Skeletal and Muscular Disorders | 3.73E-15 | - | 1.99E-02 | 123 |
Gastrointestinal Disorder | 8.25E-15 | - | 1.99E-02 | 133 |
Molecular and Cellular Signaling | p-value | #genes | ||
Cell-To-Cell Signaling and Interaction | 7.26E-20 | - | 1.99E-02 | 68 |
Cellular Assembly and Organization | 5.56E-16 | - | 1.99E-02 | 82 |
Cellular Movement | 1.28E-12 | - | 1.99E-02 | 44 |
Molecular Transport | 2.71E-07 | - | 1.99E-02 | 67 |
Small Molecule Biochemistry | 2.71E-07 | - | 1.99E-02 | 54 |
Canonical Pathways | p-value | Ratio | ||
Axonal Guidance Signaling | 1.26E-06 | 23/433 | ||
CDK5 Signaling | 3.87E-05 | 9/94 | ||
Cardiac b-adrenergic Signaling | 4.55E-05 | 11/154 | ||
Corticotropin Releasing Hormone Signaling | 2.09E-04 | 9/136 | ||
Dopamine Receptor Signaling | 6.05E-04 | 7/95 | ||
224 UPPER GENES | ||||
Molecular and Cellular Signaling | p-value | #genes | ||
Cell-To-Cell Signaling and Interaction | 4.31E-17 | - | 2.12E-02 | 51 |
Cellular Assembly and Organization | 3.34E-11 | - | 2.12E-02 | 60 |
Cellular Movement | 5.21E-10 | - | 1.42E-02 | 35 |
Cellular Function and Maintenance | 4.02E-08 | - | 2.20E-02 | 49 |
Molecular Transport | 4.02E-08 | - | 1.75E-02 | 49 |
Canonical Pathways | p-value | Ratio | ||
Corticotropin Releasing Hormone Signaling | 1.16E-04 | 8/136 | ||
CDK5 Signaling | 1.76E-04 | 7/94 | ||
Synaptic Long Term Depression | 1.62E-03 | 7/147 | ||
Cardiac b-adrenergic Signaling | 2.35E-03 | 7/154 | ||
Axonal Guidance Signaling | 2.65E-03 | 13/433 | ||
49 MID GENES | ||||
Molecular and Cellular Signaling | p-value | #genes | ||
Cellular Development | 9.09E-07 | - | 4.47E-02 | 12 |
Cell Morphology | 3.82E-06 | - | 3.88E-02 | 16 |
Cellular Assembly and Organization | 1.16E-05 | - | 4.18E-02 | 16 |
Cellular Movement | 4.59E-05 | - | 4.76E-02 | 9 |
Cell-To-Cell Signaling and Interaction | 4.00E-04 | - | 4.76E-02 | 13 |
Canonical Pathways | p-value | Ratio | ||
Axonal Guidance Signaling | 1.28E-07 | 10/433 | ||
Semaphorin Signaling in Neurons | 1.54E-05 | 4/52 | ||
Inositol Phosphate Metabolism | 7.95E-03 | 3/180 | ||
CXCR4 Signaling | 9.66E-03 | 3/169 | ||
Regulation of Actin-based Motility by Rho | 2.29E-02 | 2/91 | ||
44 DEEP GENES | ||||
Molecular and Cellular Signaling | p-value | #genes | ||
Carbohydrate Metabolism | 3.00E-05 | - | 3.88E-02 | 7 |
Molecular Transport | 3.00E-05 | - | 3.88E-02 | 11 |
Small Molecule Biochemistry | 3.00E-05 | - | 4.34E-02 | 12 |
DNA Replication, Recombination and Repair | 1.37E-04 | - | 1.81E-02 | 2 |
Nucleic Acid Metabolism | 1.37E-04 | - | 2.32E-02 | 7 |
Canonical Pathways | p-value | Ratio | ||
Protein Kinase A Signaling | 8.73E-05 | 6/328 | ||
Cardiac b-adrenergic Signaling | 3.18E-04 | 4/154 | ||
G-Protein Coupled Receptor Signaling | 1.43E-03 | 6/530 | ||
cAMP-mediated signaling | 1.94E-03 | 4/219 | ||
Synaptic Long Term Potentiation | 2.08E-03 | 3/114 | ||