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Figure 1 | BMC Neuroscience

Figure 1

From: New highly sensitive rodent and human tests for soluble amyloid precursor protein alpha quantification: preclinical and clinical applications in Alzheimer’s disease

Figure 1

Antibodies used for human and rodent sAPPα tests. For the human assay, the antibody 6E10 (specific for h-Aβ1-16) binds to a h-sAPPα epitope, which differs from the r-sAPPα by three amino acids. In the rodent assay, this antibody is substituted by a rodent Aβ1-16-specific antibody. Furthermore, this epitope is absent from sAPPβ, hence, these two C-terminal sAPPα antibodies determine the specificity of the assay whereas MAB 348 (22C11) detects both human and rodent N-terminal fragments.

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BMC Neuroscience

ISSN: 1471-2202

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