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Figure 1 | BMC Neuroscience

Figure 1

From: Exogenous erythropoietin administration attenuates intermittent hypoxia-induced cognitive deficits in a murine model of sleep apnea

Figure 1

Changes in EPO and P47phox mRNA expression in hippocampus in mice exposed to IH and SH (A). Changes in EPO mRNA expression in hippocampus of mice exposed to IH and SH compared to normoxic conditions (RA) (n = 7 per time point; * p < 0.01 IH vs. SH; # - IH vs. RA –p < 0.05). (B). Changes in NADPH oxidase P47phox subunit expression in the hippocampus of mice exposed to IH and SH (n = 7 per time point; *p < 0.01 IH vs. SH or RA). (C). Treatment with EPO significantly reduced p47phox subunit expression in the hippocampus of mice exposed to IH for 14 days (* - p < 0.01; n = 6 per condition). RA-C and IH-C refer to treatment with vehicle, while RA-EPO and IH-EPO indicate treatment with exogenous EPO.

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