Reduction in neural activation to high-calorie food cues in obese endometrial cancer survivors after a behavioral lifestyle intervention: a pilot study

Table 4 Functional Activations for High-Calorie, Low-Calorie and Non-Food Object Contrasts Post-Treatment vs. Baseline (Pre-Treatment) in Obese Endometrial Cancer Patients in a 16-Session Behavioral Lifestyle Intervention

	Brain Region (Hemisphere)	Pre-Meal (Fasted)					Post-Meal (Fed/Satiated)
		Peak Voxel					Peak Voxel
		x	y	z	Cluster Size*	t	x	y	z	Cluster Size*	t
POST < PRE TREATMENT	High Calorie vs. Low Calorie Food
	No regions survived threshold
	High Calorie vs. Non-Food Object
	Superior Frontal Gyrus (BA = 6)	38	39	30	416	-4.72
	Lateral Globus Pallidus						20	-13	6	972	-9.45
	Cingulate Gyrus (BA = 31)						-9	-23	34	968	-6.63
	Thalamus						-14	-24	5	738	-5.63
	Posterior Cingulate (BA = 29)						-8	-45	16	583	-6.52
	Precuneus (BA = 31)						-16	-44	30	811	-5.85
	Claustrum						37	-6	6	911	-6.62
	Low Calorie vs. Non-Food Object
	Insula (Bilateral; L; BA = 13)						38	-22	11	613	-5.44
	Insula (Bilateral; R; BA = 13)						-40	-13	14	691	-6.64
	Precentral Gyrus (BA = 4)						-52	-12	24	963	-10.6
	Middle Temporal Gyrus (BA = 39)						-39	-50	6	568	-4.73
POST > PRE TREATMENT	High Calorie vs. Low Calorie Food
	Superior Temporal Gyrus (BA = 22)						-48	11	-5	758	5.72
	Superior Frontal Gyrus (BA = 10)						21	63	27	607	5.90
	High Calorie vs. Non-Food Object
	No regions survived threshold
	Low Calorie vs. Non-Food Object
	No regions survived threshold

x, y, z = coordinates in Talairach space; t statistic for peak voxel; *Cluster size is reported in mm³. Results are whole brain cluster corrected for multiple comparisons; threshold α < 0.05 (min cluster size: 15–36 voxels).

ISSN: 1471-2202