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Table 3 Functional Activations for High-Calorie, Low-Calorie and Non-Food Object Contrasts at Post-Treatment in Obese Endometrial Cancer Patients Enrolled in a 16-Session Group Behavioral Lifestyle Intervention

From: Reduction in neural activation to high-calorie food cues in obese endometrial cancer survivors after a behavioral lifestyle intervention: a pilot study

     Brain Region (Hemisphere) Pre-Meal (Fasted) Post-Meal (Fed/Satiated)
Peak Voxel cPeak Voxel
x y z Cluster Size* t x y z Cluster Size* t
↑ Activation High Calorie vs. Low Calorie Food
     Declive -48 -83 -20 457 8.70      
     Declive -19 -64 -9 233 4.87      
     Inferior Frontal Gyrus (BA = 46)       44 38 12 907 8.97
     Middle Frontal Gyrus (BA = 9)       41 18 31 575 9.75
     Middle Frontal Gyrus (BA = 10)       40 62 8 479 12.5
     Anterior Cingulate (BA = 32)       -16 44 -4 403 7.63
     Insula (BA = 13)       42 11 0 182 5.94
  High Calorie vs. Non-Food Object
     Culmen (BA = 10) -4 -57 2 196 5.04      
     Middle Frontal Gyrus (BA = 6) -53 7 44 171 4.60      
  Low Calorie vs. Non-Food Object
     No regions survived threshold           
↓ Activation High Calorie vs. Low Calorie Food
     Medial Frontal Gyrus (BA = 10) 5 55 12 292 -9.68      
  High Calorie vs. Non-Food Object
     Precentral Gyrus (BA = 4) 48 -6 42 379 -4.86      
     Caudate Tail       18 -37 20 735 -10.7
     Claustrum       29 -20 16 492 -7.36
  Low Calorie vs. Non-Food Object
     Culmen 9 -58 -8 457 -7.76      
     Declive 22 -60 -13 680 -8.40      
     Cingulate Gyrus (BA = 31)       -8 -23 43 672 -11.6
     Postcentral Gyrus (BA = 3)       -56 -10 22 701 -15.3
     Insula (BA = 13)       -34 -15 21 839 -11.3
     Anterior Cingulate (BA = 24)       -9 32 13 516 -8.84
     Medial Frontal Gyrus (BA = 10)       -7 55 12 640 -8.46
  1. x, y, z = coordinates in Talairach space; t statistic for peak voxel; *Cluster size is reported in mm3. Results are whole brain cluster corrected for multiple comparisons; threshold α < 0.05 (min. cluster size: 6-38 voxels).