Skip to main content

Table 2 Effects of SDZ Ser 082 and SB 206553 on motor activity

From: SB 206553, a putative 5-HT2C inverse agonist, attenuates methamphetamine-seeking in rats

  Horizontal Activity Total Distance Vertical Activity
Vehicle 727 ± 85 189 ± 66 46 ± 10
1.0 mg/kg SDZ 572 ± 164 182 ± 65 88 ± 32
Vehicle 634 ± 66 186 ± 63 37 ± 14
5.0 mg/kg SB206 564 ± 132 107 ± 34 9 ± 3
Vehicle 379 ± 97 82 ± 42 32 ± 11
10.0 mg/kg SB206 453 ± 41 132 ± 30 11 ± 5
  1. Rats that had undergone repeated cue reactivity testing were withdrawn from methamphetamine and assessed for motor effects after pretreatment with 1.0 mg/kg SDZ Ser 082 (SDZ; 5-HT2C receptor antagonist), 5.0 mg/kg SB 206553 (SB206; putative 5-HT2C receptor inverse agonist), 10.0 mg/kg SB206 and respective vehicles. Serotonin2C receptor antagonism and inverse agonism had no effect on motor activity.