SB206 reduced reactivity to methamphetamine-associated cues. Shown are active lever presses in 15 min intervals for the first 30 min of cue reactivity (CR) testing as exhibited by rats that completed dose–response assessments of SDZ Ser 082 (SDZ; n = 10) and SB 206553 (SB206; n = 8). The x-axis legend refers to time elapsed after treatment and immediately placing the subject into the operant chamber; data represent total active lever presses between 30-45 min and 45-60 min after treatment. One statistical outlier was removed from the SDZ treatment group. (A) SDZ had no effect on active lever pressing at any dose tested (two-way rmANOVA). (B) SB206 significantly decreased active lever presses in the first 15 min of testing at 1.0, 5.0, and 10.0 mg/kg (*p < 0.05 comparing vehicle vs. 1.0 and 5.0 mg/kg SB206; ***p < 0.001 comparing vehicle vs. 10.0 mg/kg SB206; Newman-Keuls post-hoc).