Behaviour of running (28-day; RW) and control (Sedentary (con) and Blocked Wheel (blocked con)) mice during a 5-min light/dark box test. In (A), (B) and (C), entries into light box, % time spent in light box and latency to enter light box are represented respectively. N = 10 per group. In (D) the total number of DCX positive cells in the dentate gyrus from the second cohort of animals in which the light/dark box was tested are shown. *p < 0.05 vs. con, ##p < 0.01 vs. blocked con. Data represent means ± S.E.M.