Figure 1
RGC axon regeneration is similar between WldStransgenic and wildtype rats after optic nerve crush and lens injury. (A) Quantification of the mean number of RGC axons extending 250 μm past the optic nerve lesion site 14 days after either optic nerve crush alone, or in combination with lens injury in adult wildtype or WldS transgenic rats. Significant differences are indicated by asterisk (P < 0.05 = *; P < 0.01 = **). Images of RGC axon regeneration past the optic nerve lesion site (indicated by asterisk), 14 days after (B, C) optic nerve crush alone or (D, E) in combination with lens injury in wildtype and WldS transgenic rats. WT = Wildtype; ONC = Optic nerve crush; ONC + LI = Optic nerve crush + lens injury; Scale bars: 100 μm