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Figure 1 | BMC Neuroscience

Figure 1

From: Mechanisms of constitutive and ATP-evoked ATP release in neonatal mouse olfactory epithelium

Figure 1

Functional purinergic receptors expressed in the mouse olfactory epithelium. (A) Representative calcium responses from 3 cells (i-iii) elicited by application (▲) of P2Y agonist UTP (10 μM), P2X and P2Y agonist ATP (25 μM), P2X1,7 agonist BzATP (50 μM), or P2X4 agonist CTP (100 μM). (B) Normalized average peak amplitudes of agonist-elicited calcium responses (mean + SEM). * indicates p < 0.0001 v. ATP group with Bonferroni’s multiple comparison test). (C-D) Immunoreactivity of P2X7 (green) and DAPI-labeled nuclei (blue). No immunoreactivity was observed with peptide neutralization or omission of primary antibody. Dashed line, basal lamina; solid line, apical surface of OE. Scale bar: 20 μm.

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