Neural activity associated with self-reflection

BMC Neuroscience

Table 1 Analysis of the reflection period

	Brodmann area	Mean X	Mean Y	Mean Z	Cluster size (mm³)	t-max
a) Contrast (refl-self > refl-known) & (refl-self > refl-unknown)
Sup. frontal gyrus/DMPFC R, ACC/MCC	6/8/24/32	5	11	37	7132	4.7
Insula/inferior frontal gyrus R	13/45/47	36	23	2	3674	5.1
Insula/inferior frontal gyrus L	13/45/47	-36	21	6	7877	4.7
Middle frontal gyrus/DLPFC R	9	35	29	35	387	3.9
Middle frontal gyrus/DLPFC R	9/10	29	39	24	271	4.0
Middle insular cortex R	13	40	3	2	524	3.5
Midbrain	-	2	-23	0	1361	3.8
Posterior cingulate cortex	23/24	2	-16	33	1281	4.4
Caudate nucleus	-	-17	-6	23	283	3.6
Subcallosal cingulate cortex L	13	-17	11	-10	719	3.9
b) Contrast (refl-self > refl-known) & (refl-self > refl-unknown) & (refl-self > perc-self)
Insula/inferior frontal gyrus L (Figure 1A)	13/44	-38	15	8	2495	3.9
Sup. frontal gyrus/DMPFC R (Figure 1B, 2A)	6	9	1	53	1964	4.1
Middle frontal gyrus/DLPFC R (Figure 1 C)	9/10	29	39	24	386	4.0
Posterior cingulate cortex (Figure 1D)	23/24	2	-19	34	636	4.2

Activity during self-reflection significantly larger (random effects analysis, p > 0.005, p < 0.01 Monte Carlo simulation corrected) than in the known and the unknown reflection conditions.
Activation as in a) but also larger in the refl-self than in the perc-self condition.
Abbreviations: R right, L left. DLPFC dorsolateral prefrontal cortex, DMPFC dorsomedial prefrontal cortex, sup superior.

ISSN: 1471-2202