Table 1 Summary of effects compared to control, 6 days of LPS infusion on neuroinflammatory, AA cascade, and synaptic markers in rat brain
| Â | Low-dose LPS | High-dose LPS |
|---|---|---|
Neuroinflammation | ||
TNFα (protein) | ↑ | ↑ |
CD11b (protein) | No change | ↑ |
Iba-1( Protein) | No change | ↑ |
iNOS (protein) | ↑ | ↑ |
AA cascade | ||
p-cPLA2-IVA (protein) | ↑ | ↑ |
cPLA2-IVA (protein, mRNA) | No change | ↑ |
sPLA2-V (protein) | ↑ | ↑ |
COX-2 (protein, mRNA) | No change | ↑ |
5-LOX (protein, mRNA) | No change | ↑ |
Transcription regulators | ||
NF-κBp50 (activity) | No change | ↑ |
p38 MAPK (protein) | ↑ | ↑ |
Synaptic markers | ||
Synaptophysin (protein) | ↓ | ↓ (+ mRNA) |
Drebrin (protein, mRNA) | ↓ | ↓ (+ mRNA) |
PSD-95 (protein) | No Change | ↓ |