Age-dependent kinetics of dentate gyrus neurogenesis in the absence of cyclin D2

Ansorg, Anne; Witte, Otto W; Urbach, Anja

doi:10.1186/1471-2202-13-46

BMC Neuroscience

Table 1 Phenotype of newborn cells 28 days after BrdU delivery

From: Age-dependent kinetics of dentate gyrus neurogenesis in the absence of cyclin D2

		BrdU						NeuN						GFAP
		WT			KO			WT			KO			WT			KO
		mean	±	SEM	mean	±	SEM	mean	±	SEM	mean	±	SEM	mean	±	SEM	mean	±	SEM
P7		(n = 8)			(n = 3)
	BrdU abs.	62466.0	±	3239.3	22394.0	±	1455.3***	---	±	---	---	±	---	---	±	---	---	±	---
	% of BrdU+	---	±	---	---	±	---	57.4	±	2.0	60.7	±	0.3	6.3	±	1.9	4.9	±	1.2
	abs. co-lab.	---	±	---	---	±	---	35621.2	±	1643.7	13593.5	±	845.7**	3831.5	±	1060.3	1140.2	±	336.9**
P14		(n = 5)			(n = 4)
	BrdU abs.	13147.2	±	1060.1	5671.5	±	798.5**	---	±	---	---	±	---	---	±	---	---	±	---
	% of BrdU+	---	±	---	---	±	---	64.7	±	2.2	51.0	±	5.2	1.9	±	1.2	1.2	±	0.8
	abs. co-lab.	---	±	---	---	±	---	8480.3	±	649.6	2812.2	±	271.3**	223.0	±	141.4	84.3	±	63.7
P28		(n = 4)			(n = 3)
	BrdU abs.	5578.5	±	708.4	390.0	±	104.3***	---	±	---	---	±	---	---	±	---	---	±	---
	% of BrdU+	---	±	---	---	±	---	73.1	±	3.8	64.8	±	2.6	0.9	±	0.1	2.6	±	2.6
	abs. co-lab.	---	±	---	---	±	---	4100.7	±	583.4	261.1	±	88.5***	45.8	±	6.6	6.0	±	6.0
P40		(n = 3)			(n = 3)
	BrdU abs.	3726.0	±	305.2	306.0	±	51.3***	---	±	---	---	±	---	---	±	---	---	±	---
	% of BrdU+	---	±	---	---	±	---	64.6	±	4.0	60.2	±	7.1	8.3	±	4.5	12.2	±	6.5
	abs. co-lab.	---	±	---	---	±	---	2420.3	±	299.7	190.7	±	53.1***	313.5	±	186.6	31.3	±	17.0
P60		(n = 4)			(n = 4)
	BrdU abs.	2893.5	±	205.5	222.0	±	52.7***	---	±	---	---	±	---	---	±	---	---	±	---
	% of BrdU+	---	±	---	---	±	---	60.1	±	4.1	46.3	±	5.7	3.8	±	2.8	0.0	±	0.0
	abs. co-lab.	---	±	---	---	±	---	1756.7	±	219.8	101.3	±	23.6***	94.9	±	68.6	0.0	±	0.0
P90		(n = 4)			(n = 4)
	BrdU abs.	1770.0	±	354.2	205.5	±	81.5***	---	±	---	---	±	---	---	±	---	---	±	---
	% of BrdU+	---	±	---	---	±	---	66.6	±	6.6	72.5	±	14.8	5.7	±	1.5	10.8	±	7.9
	abs. co-lab.	---	±	---	---	±	---	1136.2	±	198.5	157.9	±	79.2***	107.0	±	30.1	29.7	±	18.4
P260		(n = 4)			(n = 3)
	BrdU abs.	300.0	±	60.1	26.0	±	6.2***	---	±	---	---	±	---	---	±	---	---	±	---
	% of BrdU+	---	±	---	---	±	---	49.7	±	2.0	44.4	±	29.4	9.1	±	3.2	5.6	±	5.6
	abs. co-lab.	---	±	---	---	±	---	150.0	±	33.5	13.3	±	11.4***	30.1	±	15.4	0.7	±	0.7

Two-way ANOVA on ln-transformed data (*p < 0.05, **p < 0.01, ***p < 0.001 cD2KO compared to WT); Abbreviations: abs. – absolute, abs. co-lab. – absolute number of cells co-labeled with BrdU.

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