Figure 6

BrdU-positive cell numbers are significantly reduced in cD2KO mice. As compared to WT litters BrdU incorporation is significantly reduced in cD2KO mice at all postnatal ages analyzed (p < 0.001). CD2KO animals aged P7 at first BrdU injection have already ~60% reduced BrdU-positive cell numbers as compared to WT litters. As early as P28, newborn cells are almost completely absent in cD2KO mice. In both genotypes, BrdU-positive cell numbers continuously decline during adolescence and adulthood. Statistical differences are only indicated for age-dependent changes within WT (*) and cD2KO (^#) groups (*p < 0.05, **p < 0.01, *** or ^###p < 0.001; statistics on ln-transformed values).