Figure 9
From: NF-κB p50 subunit knockout impairs late LTP and alters long term memory in the mouse hippocampus
LTP evaluation in hippocampal slices. LTP was reliably induced in both groups in CA1 hippocampus immediately after high frequency stimulation (HFS - black arrow). Early LTP time points (1, 2, and 3 hours - 5 min sampling intervals) show no significant difference in LTP responses between the two groups (P > 0.05). However, a significant decrease (*P < 0.05) was found in EPSP slope in the p50−/− hippocampal slices (triangles) vs. p50+/+ (circles) slices at 4, 5, and 6 hour time points (5 m sampling intervals) indicating deficits in late LTP. Scale bar: 2 mV, 10 ms.