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Table 3 Effects of 10 μM CCh, 2 μM AFDX, or co-application of CCh and AFDX as indicated on the maximal amplitude of the field potentials, the maximal amplitude of EPSP (EPSP max ), the I 50 and slope factor of the EPSP input–output curve

From: Distinct muscarinic acetylcholine receptor subtypes mediate pre- and postsynaptic effects in rat neocortex

  Ctl (n = 8) CCh (n = 8) CCh + AFDX (n = 8)
Field max (mV) −0.36 ± 0.09 −0.1 ± 0.04 (*) −0.26 ± 0.08 (*) (+)
EPSP max (mV) 18.9 ± 1.8 10.9 ± 1.6 (*) 15.2 ± 1.7 (*) (+)
I 50 (V) 8.45 ± 0.7 10.9 ± 0.86 (*) 9.65 ± 0.8 (*)
Slope factor 2.29 ± 0.27 3.27 ± 0.48 (*) 2.70 ± 0.33 (*)
  Ctl (n = 7) AFDX (n = 7) AFDX + CCh (n = 7)
Field max (mV) −0.79 ± 0.17 −0.99 ± 0.24 −0.67 ± 0.23
EPSP max (mV) 22.2 ± 2.4 23.9 ± 1.8 (*) 23 ± 1.8
I 50 (V) 7.42 ± 1.11 7.22 ± 1.44 8.94 ± 2.37
Slope factor 1.82 ± 0.67 2.05 ± 0.71 3.07 ± 0.75 (*) (+)
  1. The order of two drugs given in the figures indicates the sequence of application (i.e. “CCh + AFDX” means AFDX was added to a CCh containing ACSF and vice versa)
  2. These experiments were performed in STRC
  3. *: p < 0.05 vs. control, +: p < 0.05 vs. previous condition