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Table 2 Effects of 10 μM CCh, 1 μM pirenzepine, or co-application of CCh and pirenzepine, as indicated, on the maximal amplitude of the field potentials, the maximal amplitude of EPSP (EPSP max ), the I 50 and slope factor of the EPSP input–output curve

From: Distinct muscarinic acetylcholine receptor subtypes mediate pre- and postsynaptic effects in rat neocortex

  Ctl (n = 9) CCh (n = 9) CCh + pir (n = 9)
Field max (mV) −0.75 ± 0.25 −0.29 ± 0.16 (*) −0.69 ± 0.24 (+)
EPSP max (mV) 24.3 ± 1.5 20.6 ± 2 (*) 23.6 ± 1.7 (+)
I 50 (V) 5.12 ± 0.81 9.23 ± 1.71 (*) 6.22 ± 0.94 (*) (+)
Slope factor 1.61 ± 0.59 4.16 ± 0.95 (*) 1.52 ± 0.40 (+)
  Ctl (n = 7) pir (n = 7) pir + CCh (n = 7)
Field max (mV) −0.68 ± 0.3 −0.7 ± 0.29 −0.56 ± 0.25 (+)
EPSP max (mV) 20.5 ± 5.3 20.3 ± 5.1 16.0 ± 4 (*) (+)
I 50 (V) 8.41 ± 0.75 8.45 ± 0.76 9.37 ± 1.04 (*)
Slope factor 1.93 ± 0.54 2.18 ± 0.68 1.95 ± 0.31
  1. The order of two drugs given in the figures indicates the sequence of application (i.e. “CCh + pir” means pirenzepine was added to a CCh containing ACSF and vice versa)
  2. These experiments were performed in STRC
  3. *: p < 0.05 vs. control, +: p < 0.05 vs. previous condition