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Figure 6 | BMC Neuroscience

Figure 6

From: Distinct muscarinic acetylcholine receptor subtypes mediate pre- and postsynaptic effects in rat neocortex

Figure 6

CCh-induced depression of synaptic transmission is not due to blockade of M-current. A, B. Voltage traces (top traces) and field potentials (bottom traces) of a neocortical neurone in control condition (A) and in the presence of linopirdine (10 μM) (B; stimulus intensity 100 μs, 20 V). Note that linopirdine did not alter synaptic responses. C, D. Plots of average EPSP amplitudes (C; n = 12) and field potentials (D; n = 12) vs. stimulus intensity in control and in the presence of linopirdine (lino) as indicated. Note that linopirdine application decreased the amplitude of EPSP only at the highest stimulus intensities. These experiments were performed in STRC. *: p < 0.05

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