Analysis of changes in the time-dependent activation of TTX-sensitive currents by β-BuTX or indomethacin. 3A: Comparison of the activation time constants: activation time constants were estimated by single exponential fits for each voltage. Indomethacin led to acceleration of the time-dependent activation which could not reversed by β-BuTX. 3B: Comparison of the inactivation time constants: inactivation time constants were estimated by single exponential fits and plotted against the membrane potentials. Neither β-BuTX nor indomethacin showed any influence on time-dependent inactivation. (* p < 0.05; **p < 0.01; ***p < 0.001).