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Table 1 EC50values for agonist-stimulated Ca i ++ release

From: Quantitative changes in intracellular calcium and extracellular-regulated kinase activation measured in parallel in CHO cells stably expressing serotonin (5-HT) 5-HT2A or 5-HT2Creceptors

  5-HT2AR 5-HT2CR
  Serum-starved Serum-replete Serum-starved Serum-replete
5-HT 0.8 nM 53 nM 0.7 nM 4.9 nM
DOI 3.6 nM > 24 μM 5.4 nM > 100 μM
MK212 No response No response > 280 nm > 11 μM