Figure 1

Group comparisons of ALS patients versus controls. A results are superimposed on the mean of all subjects of spatially normalized anisotropy images. Voxels with a significant decrease in FA in the patients versus controls are found in the precentral gyrus, the CST and pons (p < 0,001 uncorrected). ADC results are superimposed on the mean of all subjects of spatially normalized anisotropy images. Voxels with a significant increase in ADC in the patients versus controls are found in the precentral gyrus, CST, pons, frontal ares and limbic system (p < 0,001 uncorrected).