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Table 4 Variables significantly different between AUD and control subjects

From: Evaluation of cell proliferation, apoptosis, and dna-repair genes as potential biomarkers for ethanol-induced cns alterations

Variable

 

AUD ave

Control ave

Fold Change

Nominal P

BH FDR

Medical/Demographic

  Income

2.4

5.1

-2.16

0.00003

0.013

  Years Education

13.2

15.7

-1.19

0.00007

0.015

  Blood Pressure (Systolic)

135.2

118.9

1.137

0.00364

0.070

Neuropsychological

  Full Scale IQ Percentile

53.3

83.6

-1.57

0.00024

0.025

  Full Scale IQ

101.3

118.0

-1.16

0.00025

0.018

  Verbal IQ

100.8

116.9

-1.16

0.00038

0.023

  Verbal IQ Percentile

52.3

81.6

-1.56

0.00045

0.021

  Combined Number-Sequencing Letter-Sequencing Score

10.0

13.1

-1.30

0.00058

0.025

  Performance IQ

101.4

115.7

-1.14

0.00108

0.042

  Performance IQ Percentile

53.6

80.5

-1.50

0.00115

0.041

  General Memory Percentile

51.8

80.0

-1.55

0.00146

0.048

  Auditory Immediate Memory Percentile

47.2

76.2

-1.61

0.00151

0.046

  Number Sequencing Score

9.2

12.1

-1.32

0.00176

0.046

  Visual Delayed Memory Percentile

49.4

73.9

-1.49

0.00249

0.062

  Auditory Delayed Memory Percentile

51.0

77.2

-1.51

0.00335

0.079

  Letter Fluency Score

10.0

12.9

-1.29

0.00416

0.076

  Category Fluency Score

10.9

13.7

-1.26

0.00499

0.088

  Letter Sequencing Score

9.8

12.3

-1.25

0.00517

0.087

Neuroimaging

  Right Hemisphere Temporal Superiolateral Gyrus

4674.4

5642.7

-1.21

0.00009

0.013

  Left Hemisphere Broca’s Area 45

6164.8

7197.7

-1.17

0.00025

0.021

  Left Hemisphere Frontal Inferior Triangular Gyrus

2640.2

3232.1

-1.22

0.00042

0.022

  Right Hemisphere Pars Opercularis

3956.7

4676.1

-1.18

0.00168

0.047

  Right Hemisphere Superiortemporal

11098.8

12513.5

-1.13

0.00336

0.075

  Left Hemisphere Parietal Inferior Supramarginal Gyrus

6301.8

7368.1

-1.17

0.00350

0.074

  Left Hemisphere Pars Triangularis

3537.5

4218.3

-1.19

0.00351

0.071

  Right Hemisphere Frontal Inferior Opercular Gyrus

3034.4

3493.7

-1.15

0.00540

0.088

Genes

  HUS1 checkpoint homolog (S. pombe)

493.7

558.3

-1.13

0.05221

-

  TP53 tumor protein p53

142.7

217.5

-1.52

0.01665

-

  MYC v-myc myelocytomatosis viral oncogene homolog (avian)

216.0

312.4

-1.45

0.01402

-

  MUTYH mutY homolog (E. coli)

54.5

68.0

-1.25

0.02417

-

  CDK4 cyclin-dependent kinase 4

389.8

446.3

-1.14

0.02410

-

  ERCC1 excision repair cross-complementing rodent repair deficiency, complementation group 1

627.9

735.3

-1.17

0.03782

-

  MCM5 minichromosome maintenance complex component 5

307.5

396.8

-1.29

0.02045

-

  1. Variables are grouped by category. Benjamini-Hochberg False Discovery Rate (BH FDR) was used to correct P values, except for gene data, where nominal P values are listed.