Fluoxetine prevents development of an early stress-related molecular signature in the rat infralimbic medial prefrontal cortex. Implications for depression?

Barreto, Rafael A; Walker, Frederick Rohan; Dunkley, Peter R; Day, Trevor A; Smith, Doug W

doi:10.1186/1471-2202-13-125

Table 1 Genes identified as differentially expressed by microarray analysis in the IL mPFC of rats submitted to sub-chronic restraint stress when compared to non-stress control (p≤0.05; 1.2 fold-change cut-off)

From: Fluoxetine prevents development of an early stress-related molecular signature in the rat infralimbic medial prefrontal cortex. Implications for depression?

Down-regulated genes								Up-regulated genes
MAP1B	−2.93	RGD1565549	−1.69	MLLT3	−1.55	RGD1306565	−1.44	LOC363380	1.92
BMPR2	−2.83	EEF2K	−1.69	RGD1561141	−1.54	RGD1565486	−1.44	LOC360941	1.76
LOC497804	−2.53	NRP1	−1.69	TRIO	−1.53	RGD1562123	−1.44	LOC501221	1.68
NTRK3	−2.28	KIF5C	−1.69	LOC362543	−1.53	CPD	−1.44	ALDH3B1	1.68
LOC497765	−2.24	LARP5	−1.68	LOC497681	−1.53	ASAH3L	−1.43	LOC498374	1.62
LOC309928	−2.13	RGD1307100	−1.68	GRIA3	−1.53	NCOA1	−1.43	LOC501224	1.58
MAP2	−2.09	RGD1564560	−1.68	LOC360990	−1.53	LOC291209	−1.42	LOC501093	1.55
HELZ	−2.09	TM9SF4	−1.68	GLG1	−1.53	ATRN	−1.42	LOC691487	1.54
RICS	−2.08	DSCAM	−1.68	RBBP6	−1.53	SRRM2	−1.42	LOC367381	1.49
ZFP537	−2.04	PRKCE	−1.68	LOC500867	−1.52	CDH9	−1.42	LOC691672	1.47
ODZ4	−2.00	RGD1563437	−1.67	MYT1L	−1.52	GPD2	−1.41	LOC501223	1.45
PCDH17	−1.95	USP45	−1.67	JMJD1C	−1.52	LOC362315	−1.41	RGD1561850	1.45
ODZ3	−1.95	RGD1308448	−1.66	UNC5C	−1.51	KPNB1	−1.41	GS3	1.44
RGD1566031	−1.95	RGD1307907	−1.66	SPON1	−1.51	WDFY1	−1.41	CLCC1	1.39
RIMS1	−1.93	ADD1	−1.65	LOC361942	−1.51	LOC498048	−1.41	LOC690672	1.39
ZFPM2	−1.93	CALN1	−1.65	VPS13D	−1.51	SIPA1L1	−1.41	LOC363434	1.39
ODZ3	−1.91	RGD1306245	−1.65	LOC302405	−1.51	RGD1306116	−1.41	LOC501245	1.39
AFF4	−1.89	MTMR9	−1.65	LOC363492	−1.51	ATF7IP	−1.40	LOC501089	1.39
LOC290704	−1.89	MYCL1	−1.64	RGD1566279	−1.50	NEO1	−1.40	LOC501399	1.38
APEG3	−1.88	KLF7	−1.64	LPHN1	−1.50	ABCA2	−1.40	RPL7	1.37
SGK	−1.85	RERE	−1.63	NTRK2	−1.50	CD47	−1.39	LOC691575	1.35
LOC361639	−1.85	RIMS2	−1.62	RGD1563873	−1.49	EHMT1	−1.39	LOC363320	1.35
ANK2	−1.84	TIMP2	−1.62	AKAP9	−1.49	SLC17A7	−1.39
TNR	−1.83	SEMA6A	−1.61	LRP1	−1.48	NFIA	−1.38
FALZ	−1.82	KCND2	−1.61	LOC500721	−1.48	RGS17	−1.38
KCNC2	−1.80	LOC497770	−1.60	PIM3	−1.48	RGD1305534	−1.38
LOC501548	−1.79	GSK3B	−1.60	LUC7L2	−1.47	ZFP148	−1.37
CENTG1	−1.79	NFIX	−1.60	LOC497729	−1.47	CHD3	−1.36
MDGA2	−1.78	GTF2IRD1	−1.60	OPCML	−1.46	LOC497754	−1.36
TMOD2	−1.76	PDE10A	−1.59	NEGR1	−1.46	BPHL	−1.36
LOC501637	−1.76	BRAF	−1.59	SLC1A2	−1.46	RELN	−1.36
CRIM1	−1.75	SORL1	−1.59	NRIP1	−1.45	LOC362587	−1.35
KLF5	−1.75	PUM1	−1.58	RGD1306101	−1.45	FAM108B1	−1.34
C11ORF8H	−1.74	LCP1	−1.57	MYO5A	−1.45	USP2	−1.34
SORCS1	−1.74	ZFP57	−1.57	ZDHHC13	−1.45	MAFG	−1.33
EDNRB	−1.73	ARHGAP5	−1.57	PPFIA3	−1.45	ALCAM	−1.33
TOB2	−1.73	LOC313658	−1.57	ATP2B3	−1.45	RGD1307284	−1.32
SLC38A1	−1.72	CSPG4	−1.56	MAST1	−1.45	LOC363849	−1.32
GABRB1	−1.72	LOC683578	−1.56	USP13	−1.45	CAMK2G	−1.32
RGD1310722	−1.72	KIF5A	−1.56	LOC367779	−1.45	ATP6V0A1	−1.32
PCDH19	−1.71	RGD1311049	−1.56	RGD1307696	−1.44	MPP6	−1.31
CAMK2A	−1.71	RGD1308329	−1.56	CELSR2	−1.44	EML2	−1.31
SORCS3	−1.71	SYNJ1	−1.55	DNAJC5	−1.44	LOC501145	−1.30
DUSP8	−1.70	KIF1B	−1.55	EPHA5	−1.44

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ISSN: 1471-2202

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