TY - JOUR AU - Massella, Alessandro AU - D'Intino, Giulia AU - Fernández, Mercedes AU - Sivilia, Sandra AU - Lorenzini, Luca AU - Giatti, Silvia AU - Melcangi, Roberto C. AU - Calzà, Laura AU - Giardino, Luciana PY - 2012 DA - 2012/01/24 TI - Gender effect on neurodegeneration and myelin markers in an animal model for multiple sclerosis JO - BMC Neuroscience SP - 12 VL - 13 IS - 1 AB - Multiple sclerosis (MS) varies considerably in its incidence and progression in females and males. In spite of clinical evidence, relatively few studies have explored molecular mechanisms possibly involved in gender-related differences. The present study describes possible cellular- and molecular-involved markers which are differentially regulated in male and female rats and result in gender-dependent EAE evolution and progression. Attention was focused on markers of myelination (MBP and PDGFαR) and neuronal distress and/or damage (GABA synthesis enzymes, GAD65 and GAD67, NGF, BDNF and related receptors), in two CNS areas, i.e. spinal cord and cerebellum, which are respectively severely and mildly affected by inflammation and demyelination. Tissues were sampled during acute, relapse/remission and chronic phases and results were analysed by two-way ANOVA. SN - 1471-2202 UR - https://doi.org/10.1186/1471-2202-13-12 DO - 10.1186/1471-2202-13-12 ID - Massella2012 ER -