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Table 3 Top 10 enriched functional GO clusters in GR binding regions(GBS) with and without a GRE

From: A genome-wide signature of glucocorticoid receptor binding in neuronal PC12 cells

 

GBS with GRE

GBS without GRE

GO Term

Category

Enrichment score

GO Term

Category

Enrichment score

1

cell motion

BP

4.2

neuron projection morphogenesis.

BP

3.8

2

protein kinase binding

MF

3.5

cytoplasmic vesicle

CC

2.5

3

vasculature development

BP

3.3

metal ion binding

MF

2.4

4

protein dimerization activity

MF

2.9

phospholipid binding

MF

2.3

5

metal ion binding

MF

2.8

catecholamine biosynthetic process

BP

2.2

6

regulation of apoptosis

BP

2.3

protein complex assembly

BP

2.0

7

apoptosis

BP

2.2

muscle cell development

BP

1.9

8

regulation of myeloid cell differentiation

BP

2.1

neuron projection regeneration

BP

1.6

9

cell adhesion

BP

1.9

actin filament binding

MF

1.6

10

cytoplasmic vesicle

CC

1.8

synaptic transmission

BP

1.6

  1. The 10 most enriched functional GO clusters in GBS that do or do not contain a GRE according to the Database for Annotation, Visualization and Integrated Discovery (DAVID). In both cases the GO-term that best represents the annotation cluster is shown. In addition, the category to which the GO term belongs to is indicated, i.e. Biological Processes (BP), Molecular Function (MF) or Cellular Compartment (CC). The enrichment score indicates the geometric mean (in -log scale) of p-value of the GO cluster.