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Table 2 Top 10 enriched functional GO clusters in neuronal PC12-specific GR binding regions (GBS)

From: A genome-wide signature of glucocorticoid receptor binding in neuronal PC12 cells

 

Neuronal PC212 unique GBS

GO Term

Category

Enrichment score

1

neuron development

BP

4.4

2

cytoplasmic vesicle

CC

3.4

3

neuron projection

CC

3.1

4

metal ion binding

MF

3.0

5

blood vessel development

BP

3.0

6

cell motion

BP

2.8

7

identical protein binding

MF

2.6

8

biogenic amine biosynthetic process

BP

2.6

9

synapse

CC

2.2

10

protein tyrosine kinase activity

MF

2.0

  1. Gene ontology analysis of genes associated with GBS identified in neuronal PC12 cells. The 10 most enriched functional GO clusters in GBS that are uniquely found in neuronal PC12 cells. Analysis was performed with the Database for Annotation, Visualization and Integrated Discovery (DAVID). Per cluster, the first GO-term is shown. In addition, the category to which the GO term belongs to is indicated, i.e. Biological Processes (BP), Molecular Function (MF) or Cellular Compartment (CC). The enrichment score indicates the geometric mean (in -log scale) of p-value of the GO cluster.