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Table 1 Top 50 of significance GR-binding sites

From: A genome-wide signature of glucocorticoid receptor binding in neuronal PC12 cells

Region Chr Start End p-value Nearest TS (bp) Gene symbol Gene description
1 chr14 92730207 92730300 0 58382 ddc dopa decarboxylase
2 chr12 4225730 4225800 0 41349 N4BP2L2 NEDD4 binding protein 2-like 2
3 chr8 84942839 84942945 6.66E-16 −40027 FILIP1 filamin A interacting protein 1
4 chr3 159002303 159002377 3.44E-15 −68132 ptpn1 protein tyrosine phosphate, non-receptor type 1
5 chr1 170271212 170271308 1.07E-14 38820 PARVA parvin, alpha
6 chr20 44499841 44499940 1.25E-14 −27572 CDC2L6 cell division cycle 2-like 6(CDK8-like)
7 chr1 208485510 208485587 2.67E-14 24399 FRMD8 FERM domain containing 8
8 chr10 55856373 55856471 1.24E-13 −3428 Per1 period homolog 1
9 chr10 95336367 95336493 1.82E-13 −1827 CYB561 cytochrome b-561
10 chr9 82139844 82139973 2.12E-13 −22571 AGFG1 ArfGAP with FG repeats 1
11 chr2 214126583 214126707 5.58E-13 119898 snx7 sorting nexin 7
12 chr7 71292501 71292588 1.31E-12 452930 Cohh1 Cohen syndrome homolog 1
13 chr10 108442435 108442545 1.13E-11 10507 Clqtnf1 C10q and tumor necrosis factor related protein 1
14 chr1 14981944 14982032 2.76E-11 16334 il20ra interlukin 20 receptor, alpha
15 chr10 69940043 69940119 1.777E-10 250224 ACCN1 amiloride-sensitive cation channel 1, neuronal
16 chr4 26732111 26732175 1.87E-10 −20533 cyp51 cytochrome P450, subfamily 51
17 chr1 203191165 203191336 2.39E-10 −19745 TH tyrosine hydroxylase
18 chr3 159218917 159219016 2.51E-10 −11706 Pard6b pa-6 (partitioning defective 6) homolog beta
19 chr3 11220641 11220714 2.76E-10 11081 PPAPDC3 phosphatidic acid phosphatase type 2 domain containing 3
20 chr13 98085339 98085424 8.73E-10 −40128 srp9 signal recognition particle 9
21 chr10 16132564 16132677 1.10E-09 −105921 LOC685957 cytoplasmic polyadenylation element binding protein 4
22 chr1 128794365 128794456 2.01E-09 −74086 CHD2 chromo domain helicase DNA binding protein 2
23 chr1 148370534 148370610 2.72E-09 483095 Dlg2 discs, large homolog 2
24 chr14 99179170 99179253 3.03E-09 −356843 etaa1 Ewing tumor-associated antigen 1; similar to ETAA16 protein
25 chr3 120538726 120538946 4.16E-09 -32899 CHGB chromogranin B
26 chr16 36611065 36611165 5.78E-09 −285078 HAND2 heart and neural crest derivatives expressed 2
27 chr13 100632670 100632774 6.77E-09 58963 hlx H2.0-like homeobox
28 chr1 83486283 83486376 8.07E-09 2797 ZFP36 zinc finger protein 36
29 chr2 242852558 242852668 1.23E-08 50854 sh3glb1 SH3-domain GRB2-like endophilin B1
30 chr19 36308488 36308565 1.45E-08 36674 Zfp90 zinc finger protein 90
31 chr2 218383549 218383633 1.75E-08 12542 F3 coagulation factor III (thromboplastin, tissue factor)
32 chr 72391772 72391896 2.24E-08 −85708 YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
33 chr10 63291887 6321961 2.45E-08 −26356 rph3al rabphilin 3A-like (without C2 domains)
34 CHR1 203177190 203177316 3.19E-08 −5747 TH tyrosine hydroxylase
35 chr8 121454771 121454890 4.05E-08 −35296 Snrk SNF related kinase
36 chr17 7534539 7534637 4.25E-08 90348 Npepo aminopeptidase O
37 chr7 45295426 45295501 4.78E-08 155311 PPFIA2 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha
38 chr10 19716893 19717068 6.83E-08 −7100 ccdc99 coiled-coil domain containing 99
39 chr1 179785291 179785400 7.20E-08 17710 Polr3e polymerase (RNA) III (DNA directed) polypeptide E (80kd)
40 chr13 85831724 85831796 7.86E-08 14876 DDR2 discoid in domain receptor tyrosine kinase 2
41 chr2 240315238 240315326 8.89E-08 −18368 PDLIM5 PDZ and LIM domain 5
42 chr3 155445628 155445734 1.01E-07 −503522 Sdc4 syndecan 4
43 chr16 22356139 22356299 1.05E-07 19144 SLC18A1 solute carrier family 18 (vesicular monoamine), member 1
44 chr10 75271499 75271582 1.65E-07 −112174 LOC688105 hypothetical protein LOC688105; LOC360590
45 chr16 6562495 6562603 1.71E-07 2931 NT5DC2 5’-nucleotidase domain containing 2
46 chr16 22377983 22378135 1.74E-07 21756 SLC18A1 solute carrier family 18 (vesicular monoamine), member 1
47 chr6 75731811 75731965 1.97E-07 587 NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
48 chr8 68790635 68790830 2.10E-07 −84 Rab11a RAB11a, member RAS oncogene family
49 chr8 44864109 44864180 3.27E-07 188782 SORL1 sortilin-related receptor, LDLR class A repeats-containing
50 chr8 124992930 124993041 4.02E-07 237699 Cx3cr1 chemokine (C-X3-C motif) receptor 1
  1. The 50 most significant GR-binding sites (GBS) as determined by CLCbio workbench software. Per GBS, the p-value is indicated as well as the nearest gene and the distance relative to the Transcription Start Site (TSS) of this gene. Negative numbers indicate a location upstream of the TSS, positve numbers downsteam of the TSS. GBS that are located intragenically are indicated in bold print.
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