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Table 1 Top 50 of significance GR-binding sites

From: A genome-wide signature of glucocorticoid receptor binding in neuronal PC12 cells

Region

Chr

Start

End

p-value

Nearest TS (bp)

Gene symbol

Gene description

1

chr14

92730207

92730300

0

58382

ddc

dopa decarboxylase

2

chr12

4225730

4225800

0

41349

N4BP2L2

NEDD4 binding protein 2-like 2

3

chr8

84942839

84942945

6.66E-16

−40027

FILIP1

filamin A interacting protein 1

4

chr3

159002303

159002377

3.44E-15

−68132

ptpn1

protein tyrosine phosphate, non-receptor type 1

5

chr1

170271212

170271308

1.07E-14

38820

PARVA

parvin, alpha

6

chr20

44499841

44499940

1.25E-14

−27572

CDC2L6

cell division cycle 2-like 6(CDK8-like)

7

chr1

208485510

208485587

2.67E-14

24399

FRMD8

FERM domain containing 8

8

chr10

55856373

55856471

1.24E-13

−3428

Per1

period homolog 1

9

chr10

95336367

95336493

1.82E-13

−1827

CYB561

cytochrome b-561

10

chr9

82139844

82139973

2.12E-13

−22571

AGFG1

ArfGAP with FG repeats 1

11

chr2

214126583

214126707

5.58E-13

119898

snx7

sorting nexin 7

12

chr7

71292501

71292588

1.31E-12

452930

Cohh1

Cohen syndrome homolog 1

13

chr10

108442435

108442545

1.13E-11

10507

Clqtnf1

C10q and tumor necrosis factor related protein 1

14

chr1

14981944

14982032

2.76E-11

16334

il20ra

interlukin 20 receptor, alpha

15

chr10

69940043

69940119

1.777E-10

250224

ACCN1

amiloride-sensitive cation channel 1, neuronal

16

chr4

26732111

26732175

1.87E-10

−20533

cyp51

cytochrome P450, subfamily 51

17

chr1

203191165

203191336

2.39E-10

−19745

TH

tyrosine hydroxylase

18

chr3

159218917

159219016

2.51E-10

−11706

Pard6b

pa-6 (partitioning defective 6) homolog beta

19

chr3

11220641

11220714

2.76E-10

11081

PPAPDC3

phosphatidic acid phosphatase type 2 domain containing 3

20

chr13

98085339

98085424

8.73E-10

−40128

srp9

signal recognition particle 9

21

chr10

16132564

16132677

1.10E-09

−105921

LOC685957

cytoplasmic polyadenylation element binding protein 4

22

chr1

128794365

128794456

2.01E-09

−74086

CHD2

chromo domain helicase DNA binding protein 2

23

chr1

148370534

148370610

2.72E-09

483095

Dlg2

discs, large homolog 2

24

chr14

99179170

99179253

3.03E-09

−356843

etaa1

Ewing tumor-associated antigen 1; similar to ETAA16 protein

25

chr3

120538726

120538946

4.16E-09

-32899

CHGB

chromogranin B

26

chr16

36611065

36611165

5.78E-09

−285078

HAND2

heart and neural crest derivatives expressed 2

27

chr13

100632670

100632774

6.77E-09

58963

hlx

H2.0-like homeobox

28

chr1

83486283

83486376

8.07E-09

2797

ZFP36

zinc finger protein 36

29

chr2

242852558

242852668

1.23E-08

50854

sh3glb1

SH3-domain GRB2-like endophilin B1

30

chr19

36308488

36308565

1.45E-08

36674

Zfp90

zinc finger protein 90

31

chr2

218383549

218383633

1.75E-08

12542

F3

coagulation factor III (thromboplastin, tissue factor)

32

chr

72391772

72391896

2.24E-08

−85708

YWHAZ

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide

33

chr10

63291887

6321961

2.45E-08

−26356

rph3al

rabphilin 3A-like (without C2 domains)

34

CHR1

203177190

203177316

3.19E-08

−5747

TH

tyrosine hydroxylase

35

chr8

121454771

121454890

4.05E-08

−35296

Snrk

SNF related kinase

36

chr17

7534539

7534637

4.25E-08

90348

Npepo

aminopeptidase O

37

chr7

45295426

45295501

4.78E-08

155311

PPFIA2

protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha

38

chr10

19716893

19717068

6.83E-08

−7100

ccdc99

coiled-coil domain containing 99

39

chr1

179785291

179785400

7.20E-08

17710

Polr3e

polymerase (RNA) III (DNA directed) polypeptide E (80kd)

40

chr13

85831724

85831796

7.86E-08

14876

DDR2

discoid in domain receptor tyrosine kinase 2

41

chr2

240315238

240315326

8.89E-08

−18368

PDLIM5

PDZ and LIM domain 5

42

chr3

155445628

155445734

1.01E-07

−503522

Sdc4

syndecan 4

43

chr16

22356139

22356299

1.05E-07

19144

SLC18A1

solute carrier family 18 (vesicular monoamine), member 1

44

chr10

75271499

75271582

1.65E-07

−112174

LOC688105

hypothetical protein LOC688105; LOC360590

45

chr16

6562495

6562603

1.71E-07

2931

NT5DC2

5’-nucleotidase domain containing 2

46

chr16

22377983

22378135

1.74E-07

21756

SLC18A1

solute carrier family 18 (vesicular monoamine), member 1

47

chr6

75731811

75731965

1.97E-07

587

NFKBIA

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha

48

chr8

68790635

68790830

2.10E-07

−84

Rab11a

RAB11a, member RAS oncogene family

49

chr8

44864109

44864180

3.27E-07

188782

SORL1

sortilin-related receptor, LDLR class A repeats-containing

50

chr8

124992930

124993041

4.02E-07

237699

Cx3cr1

chemokine (C-X3-C motif) receptor 1

  1. The 50 most significant GR-binding sites (GBS) as determined by CLCbio workbench software. Per GBS, the p-value is indicated as well as the nearest gene and the distance relative to the Transcription Start Site (TSS) of this gene. Negative numbers indicate a location upstream of the TSS, positve numbers downsteam of the TSS. GBS that are located intragenically are indicated in bold print.